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AD (Alzheimer's Disease) JDN Rev, mutated in 3 known mutations plus 1 in promotor region, Apolipoprotein APOE synthesized from APOE gene, soluble may be cleared by gamma secretase, Dementia by common causes Vascular dementia, Dementia by less common causes Parkinson's Disease, APP gene located on chromosome 21, ages 60+ referred to as Late onset, mild cognitive impairment present in 50% of cases, APP gene appears mutated, psychometric tests such as Abbreviated Mental Test Score (AMTS); score below 6